We sought to understand the role of vitamin D3 supplementation in alleviating chronic low back pain (CLBP). In a single-arm, open-label study at a tertiary care hospital, we worked with 68 patients suffering from CLBP for at least three months, each demonstrating a significant pain level on a visual scale alongside low vitamin D levels.
Participants received 60,000 IU of vitamin D3 weekly for eight weeks. We tracked pain intensity and functional disability at various stages: at the outset, and then at two, three, and six months post-supplementation. Notably, we witnessed a remarkable increase in vitamin D levels from an average of 12.8 ng/mL to 36.07 ng/mL in those eight weeks, with 66% of participants achieving normal vitamin D levels.
The benefits didn’t stop there. Patients reported a significant drop in their pain scores at all follow-up periods, improving from 81 to 36 on the scale. Functional ability also saw enhancement over time, proving the positive influence of vitamin D3 on both pain and everyday activities.
Overall, our findings suggest that vitamin D3 supplementation can be an effective avenue for improving pain intensity and functionality in individuals with low back pain, warranting further investigation through controlled clinical trials.
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9.5
Vitamin D aids back pain recovery
An Unusual Mimic of Axial Spondyloarthritis: A Case Report.
We observed a fascinating case involving a male in his 40s who experienced persistent inflammatory back pain for three months. Despite having a negative test for HLA-B27, a marker often associated with axial spondyloarthritis, clinical assessments suggested possible underlying issues.
The clinical investigation led to an MRI, which confirmed bilateral symmetrical sacroiliitis. Interestingly, further tests showed he had very low vitamin D levels along with elevated parathyroid hormone—indicating a possible deficiency impacting his condition.
After starting treatment with vitamin D alongside nonsteroidal anti-inflammatory drugs (NSAIDs), he experienced notable relief from his symptoms. His condition improved significantly, and follow-up tests indicated that his vitamin D levels had normalized.
This case demonstrates the potential benefits of vitamin D in managing back pain, especially when classical markers are inconclusive. It highlights how a thorough diagnosis can reveal interconnected health issues and improve treatment outcomes.
Read More
8
Vitamin D alleviates back pain
The effectiveness of vitamin D3 supplementation in improving functional outcome of non-surgically treated symptomatic lumbar spinal stenosis: Randomized controlled clinical trial - Pilot study.
We conducted a randomized controlled trial to investigate how vitamin D supplementation might alleviate lower back pain in patients suffering from lumbar spinal stenosis. This study involved patients with severely low vitamin D levels, specifically under 10 ng/mL. Participants were divided into two groups: one received vitamin D supplements, while the other did not.
Over a period of several weeks, we measured pain levels and functional recovery using simple questionnaires and health surveys. Notably, we observed that those who received vitamin D injections reported significant improvements in their back pain and overall quality of life compared to those who didn’t.
Our findings suggest that addressing vitamin D deficiency might play a crucial role in managing back pain for individuals with spinal stenosis who are not candidates for surgical intervention. The results demonstrate a promising correlation between high-dose vitamin D supplementation and enhanced functional outcomes in these patients.
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Most Useful Reviews
9
Relieved back pain
4 people found this helpful
After childbirth, I had pubic area pain. My doctor prescribed calcium with vitamin D, but I realised I consumed enough calcium. It was vitamin D that corrected my deficiency and helped with calcium absorption. After two weeks, I felt relief, and the pain disappeared. Now I take one capsule daily for prevention. This vitamin also supports the immune system.
Read More
9
No bone pain
3 people found this helpful
Vitamin D is fantastic! I've been taking it for about six months. My leg bones ached and crunched, but since taking this vitamin, I have had no pain. I've also started giving it to my children!
Read More
9
Enhanced immunity
1 people found this helpful
Vitamin D3 is essential for immunity and bone health! Following a test indicating low levels, I took this supplement for three months, which normalised my vitamin D levels. My energy and mood soared, and my overall health improved. I wholeheartedly recommend this effective product from Solgar.
We observed a fascinating case involving a male in his 40s who experienced persistent inflammatory back pain for three months. Despite having a negative test for HLA-B27, a marker often associated with axial spondyloarthritis, clinical assessments suggested possible underlying issues.
The clinical investigation led to an MRI, which confirmed bilateral symmetrical sacroiliitis. Interestingly, further tests showed he had very low vitamin D levels along with elevated parathyroid hormone—indicating a possible deficiency impacting his condition.
After starting treatment with vitamin D alongside nonsteroidal anti-inflammatory drugs (NSAIDs), he experienced notable relief from his symptoms. His condition improved significantly, and follow-up tests indicated that his vitamin D levels had normalized.
This case demonstrates the potential benefits of vitamin D in managing back pain, especially when classical markers are inconclusive. It highlights how a thorough diagnosis can reveal interconnected health issues and improve treatment outcomes.
Read More
9.5
Pregnancy osteoporosis therapy outcomes
Successful neridronate therapy in pregnancy-associated osteoporosis.
We observed a rare condition known as pregnancy-associated osteoporosis, which affected a 38-year-old woman after she gave birth. Just a month postpartum, she experienced sudden back pain due to four vertebral fractures, and her bone density was notably low, especially in the spine.
While the patient's biochemical tests were largely normal, we noted some concerning markers, including elevated urinary deoxypyridinoline and slightly reduced levels of serum vitamin D3. To address her symptoms and improve her bone health, a combination therapy consisting of neridronate, calcium, and cholecalciferol (vitamin D3) was initiated.
Encouragingly, after one month on this treatment, she reported being pain-free. Moreover, a follow-up bone density scan after six months indicated a significant improvement in her bone density in both the spine and hip areas. This suggests that while neridronate played a crucial role, it's also important to recognize the potential benefits of vitamin D3 within this treatment regimen. However, since the effects were part of a combination therapy, we cannot isolate the specific impact of vitamin D3 on back pain alone.
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9.5
PLO treatment and vitamin D3
Effective treatment of severe pregnancy and lactation-related osteoporosis with teriparatide: case report and review of the literature.
We explored the impact of various treatments, including vitamin D3, on severe back pain caused by pregnancy-related osteoporosis (PLO). In a significant case study, a 23-year-old woman experiencing debilitating back pain was treated after her first childbirth. By monitoring her bone mineral density, we noted low T- and Z-scores in her lumbar spine.
The treatment plan included teriparatide, calcium, and vitamin D3. While we observed substantial improvements in bone density and relief from pain, it’s important to note that the isolated effect of vitamin D3 is difficult to pinpoint due to its combination with other treatments.
Overall, while vitamin D3 plays a notable role alongside teriparatide in managing back pain linked to PLO, its individual effectiveness remains somewhat unclear.
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9
Vitamin D aids back pain relief
Adult-onset hypophosphatemic osteomalacia as a cause of widespread musculoskeletal pain: A retrospective case series of single center experience.
We conducted a retrospective review to uncover how vitamin D treatment impacts back pain in individuals diagnosed with adult-onset hypophosphatemic osteomalacia. In our exploration, we found that eight patients, primarily experiencing widespread musculoskeletal pain, were assessed over a span from January 2011 to December 2019.
Each patient presented with low phosphorus levels, elevated alkaline phosphatase, and indicative imaging results. Notably, back pain was reported as the most common complaint, along with muscle weakness in over half of the cases. Our findings highlighted the effectiveness of vitamin D in tandem with phosphorus supplementation, as all patients reported significant improvements in pain, muscle strength, and gait after receiving treatment.
Importantly, we noted that the specific diagnosis of each patient varied. In six cases, treatment was prompted by adefovir-induced Fanconi syndrome, while the remaining two patients had tumor-induced osteomalacia and light-chain nephropathy. This variation indicates the diverse etiologies of hypophosphatemic osteomalacia, further emphasizing the importance of targeted treatment based on individual needs.
In conclusion, our study suggests that vitamin D, especially when combined with phosphorus, plays a crucial role in alleviating back pain associated with this condition. By enhancing the understanding of the relationship between vitamin D treatment and back pain, we aim to shed light on effective management strategies for those suffering from similar symptoms.
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9
Denosumab improves back pain outcomes
Effectiveness of denosumab on back pain-related disability and quality-of-life in patients with vertebral fragility fractures.
We explored the effectiveness of denosumab on alleviating back pain and enhancing quality of life in post-menopausal women suffering from vertebral fractures. This study, involving 140 women aged around 70, assessed participants who received denosumab alongside calcium and vitamin D3 for a year.
While treatment with denosumab led to significant improvements in back pain disability, overall physical and mental health quality metrics, including the Spine Pain Index and the EuroQol-5D scale, were markedly more effective post-treatment.
The ongoing role of vitamin D3 remains obscured, as it was part of a combined regimen that made it challenging to isolate its individual effects on back pain. Thus, while we observed clear benefits from the denosumab treatment, the unique contribution of vitamin D3 to back pain relief requires further investigation.
After childbirth, I had pubic area pain. My doctor prescribed calcium with vitamin D, but I realised I consumed enough calcium. It was vitamin D that corrected my deficiency and helped with calcium absorption. After two weeks, I felt relief, and the pain disappeared. Now I take one capsule daily for prevention. This vitamin also supports the immune system.
Read More
9
No bone pain
3 people found this helpful
Vitamin D is fantastic! I've been taking it for about six months. My leg bones ached and crunched, but since taking this vitamin, I have had no pain. I've also started giving it to my children!
Read More
9
Enhanced immunity
1 people found this helpful
Vitamin D3 is essential for immunity and bone health! Following a test indicating low levels, I took this supplement for three months, which normalised my vitamin D levels. My energy and mood soared, and my overall health improved. I wholeheartedly recommend this effective product from Solgar.
Read More
0
Worsened back pain
I bought this for a fracture, but my heart began racing, and I experienced worse nocturia and sudden sharp pain in my back. The quality seems poor, and I had no such side effects with other brands. The dosage isn’t high, but I definitely noticed these ridiculous symptoms.
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7.5
No back pain
5 people found this helpful
Very effective D3! I took it with my husband from September to May, one cap in the morning and evening with meals. The result is remarkable: a convenient dose of 1000mg helped prevent illness; we only had a runny nose at worst. My back pain ceased completely, which is surprising after only one course of treatment. We definitely plan to stock up for the cold season. I’m very pleased with the quality and prices!
Back pain is a common ailment that affects millions of people worldwide and can vary significantly in intensity and duration. It can be classified into two main categories: acute and chronic. Acute back pain often arises suddenly due to a specific injury or strain, while chronic back pain persists for a longer duration, typically defined as lasting for 12 weeks or more. The pain can occur in various regions of the back, including the lower, middle, or upper sections, and may be accompanied by additional symptoms such as stiffness, muscle spasms, or reduced mobility.
Causes of back pain can range from poor posture, overexertion, or lifting heavy objects incorrectly to more serious conditions such as herniated discs, arthritis, or spinal abnormalities. Treatment options usually depend on the underlying cause and may include rest, physical therapy, medications, or, in some cases, surgical interventions. Maintaining a healthy lifestyle through regular exercise, proper ergonomics, and strength training can help prevent back pain and improve overall spinal health.
Vitamin D is a fat-soluble vitamin that's essential for maintaining healthy bones and teeth, supporting immune system function, and facilitating normal cell growth and development. It plays a crucial role in calcium absorption in the gut, which is vital for bone health. Unlike most vitamins, our bodies can produce Vitamin D when exposed to sunlight, specifically UVB rays, which is why it’s often referred to as the "sunshine vitamin." However, depending on your geographical location, lifestyle, and skin type, getting sufficient Vitamin D from the sun alone can be challenging, particularly during the winter months.
In addition to sunlight, Vitamin D can be obtained from certain foods such as fatty fish (like salmon and mackerel), fish liver oils, and fortified foods like milk and cereals. Some individuals may also consider supplements, especially if they're at risk for deficiency. Insufficient vitamin D levels are linked to various health issues, including rickets in children, osteomalacia in adults, and even an increased risk of chronic diseases. Regularly checking your vitamin D levels and consulting with a healthcare professional can help ensure you're meeting your needs for optimal health.
Vitamin D plays a crucial role in overall health, particularly for musculoskeletal wellness, but its direct effects on back pain are still a topic of ongoing research. Some studies suggest that low levels of Vitamin D may be associated with increased body pain and discomfort, including in the back. Since Vitamin D contributes to bone health and muscle function, adequate levels might help alleviate pain for individuals with deficiencies. If you find yourself struggling with back pain and suspect you might not be getting enough Vitamin D, consider discussing this with your healthcare provider.
However, it’s important to note that Vitamin D alone is unlikely to be a panacea for back pain. Effective treatment often requires a multi-faceted approach that may include physical therapy, exercise, proper posture, and possibly medication, depending on the underlying cause of the pain. While ensuring you're getting enough Vitamin D is a smart component of a healthy lifestyle, it's best to consider it as part of a broader strategy for managing back pain instead of a standalone solution.
Based on user reviews, the time it takes to see results from taking Vitamin D supplements for back pain varies among individuals. Some users report experiencing significant relief within a week of starting the supplement. For instance, one reviewer noted a "significant reduction in joint pain" after just a week of use Read Review. Others, like one who mentioned they took it for a longer duration, found their back pain subsided after about two weeks Read Review.
Conversely, there are accounts of individuals who needed a longer period to notice an improvement, with some stating they took the supplement for up to three months before they felt normal and their overall health improved Read Review. Overall, while many users do experience benefits fairly quickly, it’s essential to keep in mind that individual responses to supplements can vary significantly, and factors such as dosage and personal health conditions may influence the time frame for relief.
No, the supplement, particularly vitamin D, is not strongly supported by scientific research for the treatment of back pain. Several studies have explored the connection between vitamin D levels and back pain, but the overall consensus suggests limited efficacy. For example, a systematic review of randomized controlled trials concluded that vitamin D supplementation did not produce significant reductions in pain levels for those with chronic low back pain (CLBP), regardless of their initial vitamin D status [1]. Although some individual cases indicate potential benefits, such as relief observed when treating co-existing conditions or deficiencies, these findings are not substantial enough to recommend vitamin D as a standalone treatment for back pain.
In addition, while some studies have shown that vitamin D supplementation, especially when combined with other treatments, can lead to improvements in pain and quality of life, it remains difficult to isolate its effects solely related to back pain [4]. Therefore, while maintaining adequate vitamin D levels is essential for overall health and may play a role in a broader treatment strategy, relying on vitamin D alone for addressing back pain lacks robust support from the current scientific literature.
Based on user reviews, many individuals have reported significant improvements in symptoms after incorporating Vitamin D supplements into their daily routines. One user shared that after dealing with pubic area pain post-childbirth, they experienced relief within just two weeks of taking Vitamin D, attributing the disappearance of their pain to the supplement's effectiveness in correcting their deficiency and aiding calcium absorption Read Review. Similarly, another reviewer noted that their persistent leg pain vanished after six months of taking the vitamin, and they even decided to give it to their children Read Review.
Additionally, some users experienced rapid relief, with one noting a significant reduction in joint pain and improved mood and sleep after just a week of use Read Review. Another couple reported that after taking Vitamin D3 throughout the colder months, their back pain ceased completely and they only encountered mild illnesses Read Review. While these accounts are encouraging, it's important to remember that individual results may vary, and what works for one person might differ for another.
Based on user reviews, there appears to be a trend of individuals combining Vitamin D supplements with other dietary aids to manage back pain effectively. For instance, one reviewer shared their positive experience of taking Vitamin D along with Omega supplements, stating that the combination contributed significantly to their recovery during a challenging winter period Read Review. Another user mentioned that they incorporated multivitamins along with Vitamin D during fall, which they felt had a substantial impact on their overall well-being Read Review.
Additionally, several users reported that Vitamin D alone has been beneficial for alleviating back pain without needing many supplementary adjustments. One individual noted that after taking Vitamin D, not only did their back pain subside, but their overall health flourished, allowing them to resume normal activities Read Review. Similarly, another user confirmed that this supplement effectively relieved their back pain, suggesting that its efficacy might be enhanced when combined with a holistic approach, including dietary considerations Read Review. Overall, while many users experienced successful outcomes combining Vitamin D with other supplements, individual results can vary significantly.
Based on user reviews, individuals have reported varying doses of Vitamin D that they believe effectively alleviated back pain. One user highlighted the benefits of taking 1000mg of Vitamin D3 twice daily, noting a complete cessation of back pain after just one course of treatment Read Review. Another review indicated a recommendation from a doctor to take 2000 units daily due to severe vitamin D deficiency, which helped reduce back pain over time Read Review. Furthermore, a user taking one capsule twice a day reported significant health improvements, including relief from bone pain, which they attributed to regular Vitamin D intake Read Review.
Users generally suggest starting Vitamin D supplementation based on medical advice, especially following tests that reveal low levels. For instance, another user noted the importance of monitoring their vitamin D levels while taking the supplement consistently and experiencing less pain Read Review. These insights indicate that personalized dosing, informed by medical expertise and individual health conditions, may be key to effectively using Vitamin D for back pain relief.
7.5
Reduced joint pain
3 people found this helpful
Excellent! After just a week, I noticed a significant reduction in joint pain, better sleep, and improved mood - all alongside a healthy diet.
7.5
No back pain
5 people found this helpful
Very effective D3! I took it with my husband from September to May, one cap in the morning and evening with meals. The result is remarkable: a convenient dose of 1000mg helped prevent illness; we only had a runny nose at worst. My back pain ceased completely, which is surprising after only one course of treatment. We definitely plan to stock up for the cold season. I’m very pleased with the quality and prices!
9
Enhanced immunity
1 people found this helpful
Vitamin D3 is essential for immunity and bone health! Following a test indicating low levels, I took this supplement for three months, which normalised my vitamin D levels. My energy and mood soared, and my overall health improved. I wholeheartedly recommend this effective product from Solgar.
9
Relieved back pain
4 people found this helpful
After childbirth, I had pubic area pain. My doctor prescribed calcium with vitamin D, but I realised I consumed enough calcium. It was vitamin D that corrected my deficiency and helped with calcium absorption. After two weeks, I felt relief, and the pain disappeared. Now I take one capsule daily for prevention. This vitamin also supports the immune system.
9
No bone pain
3 people found this helpful
Vitamin D is fantastic! I've been taking it for about six months. My leg bones ached and crunched, but since taking this vitamin, I have had no pain. I've also started giving it to my children!
9
Managed back pain
4 people found this helpful
I believe it helped! My family and I took one capsule twice a day, enduring serious life challenges during winter. The initial months were tough; we were all exhausted and emotionally drained. On a doctor's advice, we started a course of Solgar D3 and Omega. After two weeks, I was pleasantly surprised to recover and could work again by February.
9
Eased back pain
2 people found this helpful
This lifesaving capsule helped me survive the harsh northern months of November and December when the sun is absent. Since I began taking it in spring, I found autumn much easier to manage. In the fall, I also took multivitamins with vitamin D. This combination significantly contributed to my well-being.
7.5
Reduced back pain
1 people found this helpful
This vitamin D from a trusted brand is quite good. Although my level was 25, I followed an endocrinologist's advice and took it for six months. I didn't get sick, just the occasional runny nose. Remarkably, my back pain subsided, and I am delighted with the quality and dosage options.
9
Trustworthy for back pain
I trust Slagor supplements. I took this for my back pain, and it worked well for me.
6
Recovery from deficiency
1 people found this helpful
I have ordered this product twice as it arrived in good condition with no unusual smells. The cost-to-quality ratio is excellent. Following my endocrinologist’s advice due to severe vitamin D deficiency, I am returning to normal. I take 2000 units each day, and my colleague is prescribed a different dosage, so testing is advisable.
7.5
Improved back pain
4 people found this helpful
A high-quality dietary supplement! I noticed results within days, taken for hair loss and bone pain, as recommended by my doctor. I took one capsule twice a day with meals. My health improved significantly; I no longer felt broken in the mornings, and my skin and hair improved. I’m thrilled with this miracle!
2
Vitamin D ineffective for back pain
Updated Meta-analysis Reveals Limited Efficacy of Vitamin D Supplementation in Chronic Low Back Pain.
We examined the effectiveness of vitamin D supplementation for people dealing with chronic low back pain (CLBP). Through a systematic review of randomized controlled trials, we focused on understanding whether vitamin D could bring any relief to those suffering from this persistent discomfort.
Our analysis of ten trials found that vitamin D supplementation did not lead to significant reductions in pain levels compared to control groups. This held true regardless of participants' initial vitamin D levels, and even long-term use did not show considerable improvements in pain outcomes. Interestingly, using active forms of vitamin D also failed to provide the hoped-for relief.
Despite these findings, it’s important to note that vitamin D might still play a role in a broader treatment plan for CLBP. However, as of now, there isn’t enough evidence to suggest that it can independently alleviate the pain. Further investigation is necessary to understand the potential long-term effects and the reasons behind the lack of benefit observed in our study.
8
Effectiveness of combined treatments
Combined Rehabilitation with Alpha Lipoic Acid, Acetyl-L-Carnitine, Resveratrol, and Cholecalciferolin Discogenic Sciatica in Young People: A Randomized Clinical Trial.
We explored how a combination of treatments, including a specific vitamin D supplement (Cholecalciferol), could help alleviate back pain in young people suffering from sciatica due to herniated discs. In this study, we looked at 128 patients divided into three groups. One group received a combination of rehabilitation therapy and daily supplements, while the second group only underwent rehabilitation. The third group was given supplements without the additional therapy.
Over a span of 60 days, we measured improvements in pain levels, disability, and quality of life using various rating scales. We found that the group receiving both rehabilitation and supplements saw significant improvements in pain and overall quality of life after 30 days. However, after two months, while they still had better outcomes in pain and quality of life compared to the other groups, the vitamin D's individual effect couldn’t be distinctly isolated.
Ultimately, our findings suggest that while vitamin D was part of an effective treatment plan that included other beneficial supplements, we cannot attribute all the improvements in back pain directly to vitamin D alone. This highlights the importance of comprehensive treatment approaches for conditions like sciatica.
References
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Bose S, Mohanasundaram K, Rajalakshmi KV, Perumal Kumaresan A, Simon J. An Unusual Mimic of Axial Spondyloarthritis: A Case Report. Cureus. 2024;16:e61441. 10.7759/cureus.61441
V N, Nair GG, Jose BC, Abraham A. Study on Vitamin D Levels in 30 to 40-Year-Old Females With Low Back Pain. Cureus. 2024;16:e54238. 10.7759/cureus.54238
Scaturro D, Vitagliani F, Tomasello S, Sconza C, Respizzi S, et al. Combined Rehabilitation with Alpha Lipoic Acid, Acetyl-L-Carnitine, Resveratrol, and Cholecalciferolin Discogenic Sciatica in Young People: A Randomized Clinical Trial. Medicina (Kaunas). 2023;59. 10.3390/medicina59122197
Kim S, Kim SW, Lee BC, Kim DH, Sung DH. Adult-onset hypophosphatemic osteomalacia as a cause of widespread musculoskeletal pain: A retrospective case series of single center experience. World J Clin Cases. 2023;11:7785. 10.12998/wjcc.v11.i32.7785
Ko S, Kim HC, Kwon J. The effectiveness of vitamin D3 supplementation in improving functional outcome of non-surgically treated symptomatic lumbar spinal stenosis: Randomized controlled clinical trial - Pilot study. Medicine (Baltimore). 2023;102:e32672. 10.1097/MD.0000000000032672
Evangelatos G, Kouna K, Iliopoulos A, Fragoulis GE. Musculoskeletal Complications of Celiac Disease: A Case-Based Review. Mediterr J Rheumatol. 2023;34:86. 10.31138/mjr.34.1.86
Dechsupa S, Yingsakmongkol W, Limthongkul W, Singhatanadgige W, Jitjumnong M, et al. Vitamin D Inadequacy Affects Skeletal Muscle Index and Physical Performance in Lumbar Disc Degeneration. Int J Mol Sci. 2023;24. 10.3390/ijms24043152
Zhang W, Li L, Zhou X, Li K, Liu C, et al. Concurrent Treatment with Vitamin K2 and D3 on Spine Fusion in Patients with Osteoporosis-Associated Lumbar Degenerative Disorders. Spine (Phila Pa 1976). 2022;47:352. 10.1097/BRS.0000000000004309
Ma Y, Wu X, Xiao X, Ma Y, Feng L, et al. Effects of teriparatide versus percutaneous vertebroplasty on pain relief, quality of life and cost-effectiveness in postmenopausal females with acute osteoporotic vertebral compression fracture: A prospective cohort study. Bone. 2020;131:115154. 10.1016/j.bone.2019.115154
Pishgahi A, Dolatkhah N, Shakouri SK, Hashemian M, Amiri A, et al. Lower serum 25-hydroxyvitamin D3 concentration is associated with higher pain and disability in subjects with low back pain: a case-control study. BMC Res Notes. 2019;12:738. 10.1186/s13104-019-4768-0
Krasowska K, Skrobot W, Liedtke E, Sawicki P, Flis DJ, et al. The Preoperative Supplementation With Vitamin D Attenuated Pain Intensity and Reduced the Level of Pro-inflammatory Markers in Patients After Posterior Lumbar Interbody Fusion. Front Pharmacol. 2019;10:527. 10.3389/fphar.2019.00527
Moretti A, de Sire A, Curci C, Toro G, Gimigliano F, et al. Effectiveness of denosumab on back pain-related disability and quality-of-life in patients with vertebral fragility fractures. Curr Med Res Opin. 2019;35:151. 10.1080/03007995.2018.1545636
Brady SRE, Naderpoor N, de Courten MPJ, Scragg R, Cicuttini F, et al. Vitamin D supplementation may improve back pain disability in vitamin D deficient and overweight or obese adults. J Steroid Biochem Mol Biol. 2019;185:212. 10.1016/j.jsbmb.2018.09.005
Dzik K, Skrobot W, Flis DJ, Karnia M, Libionka W, et al. Vitamin D supplementation attenuates oxidative stress in paraspinal skeletal muscles in patients with low back pain. Eur J Appl Physiol. 2018;118:143. 10.1007/s00421-017-3755-1
Englund M, Persson J, Bergström I. Lower pain and higher muscular strength in immigrant women with vitamin D deficiency following vitamin D treatment. Int J Circumpolar Health. 2017;76:1340547. 10.1080/22423982.2017.1340547
Gaudio A, Fiore CE. Successful neridronate therapy in pregnancy-associated osteoporosis. Clin Cases Miner Bone Metab. 2016;13:241. 10.11138/ccmbm/2016.13.3.241
Ghai B, Bansal D, Kanukula R, Gudala K, Sachdeva N, et al. Vitamin D Supplementation in Patients with Chronic Low Back Pain: An Open Label, Single Arm Clinical Trial. Pain Physician. 2017;20:E99.
Tanaka S, Yoshida A, Kono S, Oguma T, Hasegawa K, et al. Effectiveness of elcatonin for alleviating pain and inhibiting bone resorption in patients with osteoporotic vertebral fractures. J Bone Miner Metab. 2017;35:544. 10.1007/s00774-016-0791-6
Polat SB, Evranos B, Aydin C, Cuhaci N, Ersoy R, et al. Effective treatment of severe pregnancy and lactation-related osteoporosis with teriparatide: case report and review of the literature. Gynecol Endocrinol. 2015;31:522. 10.3109/09513590.2015.1014787
Gendelman O, Itzhaki D, Makarov S, Bennun M, Amital H. A randomized double-blind placebo-controlled study adding high dose vitamin D to analgesic regimens in patients with musculoskeletal pain. Lupus. 2015;24:483. 10.1177/0961203314558676
Shin MY, Kang YE, Kong SE, Ju SH, Back MK, et al. A case of low bone mineral density with vitamin d deficiency due to prolonged lactation and severe malnutrition. J Bone Metab. 2015;22:39. 10.11005/jbm.2015.22.1.39